| Abbeville Area Medical Center | Abbeville | Critical Access Hospitals | — | 196 |
| Aiken Regional Medical Center | Aiken | Acute Care Hospitals | 2 | 523 |
| Anmed Health | Anderson | Acute Care Hospitals | 4 | 681 |
| Patrick B Harris Psychiatric Hospital | Anderson | Psychiatric | — | 0 |
| Beaufort County Memorial Hospital | Beaufort | Acute Care Hospitals | 4 | 710 |
| Nh Beaufort | Beaufort | Acute Care - Department of Defense | — | 0 |
| Kershawhealth | Camden | Acute Care Hospitals | 3 | 364 |
| Bon Secours-St Francis Xavier Hospital | Charleston | Acute Care Hospitals | 3 | 1,027 |
| Charleston VA Medical Center | Charleston | Acute Care - Veterans Administration | 5 | 0 |
| Musc Medical Center | Charleston | Acute Care Hospitals | 2 | 2,772 |
| Palmetto Lowcountry Behavioral Health | Charleston | Psychiatric | — | 0 |
| Roper Hospital | Charleston | Acute Care Hospitals | 4 | 1,115 |
| Trident Medical Center | Charleston | Acute Care Hospitals | 3 | 886 |
| McLeod Health Cheraw | Cheraw | Acute Care Hospitals | 3 | 229 |
| Musc Health Chester Medical Center | Chester | Acute Care Hospitals | — | 104 |
| Prisma Health Laurens County Hospital | Clinton | Acute Care Hospitals | 4 | 231 |
| Columbia SC VA Medical Center | Columbia | Acute Care - Veterans Administration | 5 | 0 |
| G Werber Bryan Psych Hosp | Columbia | Psychiatric | — | 0 |
| Musc Health Columbia Medical Center Downtown | Columbia | Acute Care Hospitals | 3 | 791 |
| Prisma Health Baptist | Columbia | Acute Care Hospitals | 4 | 854 |
| Prisma Health Baptist Parkridge | Columbia | Acute Care Hospitals | 4 | 547 |
| Prisma Health Richland Hospital | Columbia | Acute Care Hospitals | 3 | 1,465 |
| Conway Medical Center | Conway | Acute Care Hospitals | 2 | 542 |
| Lighthouse Behavioral Health Hospital | Conway | Psychiatric | — | 0 |
| McLeod Medical Center - Dillon | Dillon | Acute Care Hospitals | 3 | 216 |
| Prisma Health Baptist Easley Hospital | Easley | Acute Care Hospitals | 4 | 521 |
| Edgefield County Healthcare An Affiliate of Self R | Edgefield | Critical Access Hospitals | — | 95 |
| Allendale County Hospital | Fairfax | Critical Access Hospitals | — | 56 |
| McLeod Regional Medical Center-Pee Dee | Florence | Acute Care Hospitals | 3 | 1,082 |
| Musc Health Florence Medical Center | Florence | Acute Care Hospitals | 3 | 755 |
| Cherokee Medical Center | Gaffney | Acute Care Hospitals | 2 | 450 |
| Tidelands Georgetown Memorial Hospital | Georgetown | Acute Care Hospitals | 2 | 700 |
| Prisma Health Patewood Hospital | Greenville | Acute Care Hospitals | 5 | 1,018 |
| Prisma Health Greenville Memorial Hospital | Greenville | Acute Care Hospitals | 4 | 2,163 |
| Shriners Hospitals for Children | Greenville | Childrens | — | 0 |
| St Francis-Downtown | Greenville | Acute Care Hospitals | 4 | 1,095 |
| Self Regional Healthcare | Greenwood | Acute Care Hospitals | 4 | 625 |
| Carolina Ctr for Behavioral Health,the | Greer | Psychiatric | — | 0 |
| Pelham Medical Center | Greer | Acute Care Hospitals | 5 | 634 |
| Coastal Carolina Hospital | Hardeeville | Acute Care Hospitals | 4 | 361 |
| Carolina Pines Regional Medical Center | Hartsville | Acute Care Hospitals | 2 | 180 |
| Novant Health Hilton Head Medical Center | Hilton Head Island | Acute Care Hospitals | 2 | 413 |
| Musc Health Lancaster Medical Center | Lancaster | Acute Care Hospitals | 4 | 286 |
| Rebound Behavioral Health | Lancaster | Psychiatric | — | 0 |
| McLeod Loris Hospital | Loris | Acute Care Hospitals | 4 | 848 |
| McLeod Health Clarendon | Manning | Acute Care Hospitals | 3 | 302 |
| Mount Pleasant Hospital | Mount Pleasant | Acute Care Hospitals | 5 | 713 |
| Novant Health East Cooper Medical Center | Mount Pleasant | Acute Care Hospitals | 4 | 249 |
| Musc Health Marion Medical Center | Mullins | Acute Care Hospitals | 3 | 207 |
| Tidelands Waccamaw Community Hospital | Murrells Inlet | Acute Care Hospitals | 4 | 791 |
| Grand Strand Regional Medical Center | Myrtle Beach | Acute Care Hospitals | 2 | 763 |
| Newberry County Memorial Hospital | Newberry | Acute Care Hospitals | 3 | 172 |
| Cannon Memorial Hospital | Pickens | Acute Care Hospitals | — | 95 |
| Piedmont Medical Center | Rock Hill | Acute Care Hospitals | 2 | 550 |
| Prisma Health Oconee Memorial Hospital | Seneca | Acute Care Hospitals | 4 | 729 |
| Prisma Health Hillcrest Hospital | Simpsonville | Acute Care Hospitals | 4 | 796 |
| Prisma Health Greer Memorial Hospital | Spartanburg | Acute Care Hospitals | 5 | 920 |
| Spartanburg Medical Center | Spartanburg | Acute Care Hospitals | 2 | 1,276 |
| Roper St Francis Hospital-Berkeley Inc | Summerville | Acute Care Hospitals | 5 | 930 |
| Prisma Health Tuomey Hospital | Sumter | Acute Care Hospitals | 3 | 473 |
| Springbrook Behavioral Health System | Travelers Rest | Psychiatric | — | 0 |
| Union Medical Center | Union | Acute Care Hospitals | — | 324 |
| Hampton Regional Medical Center | Varnville | Acute Care Hospitals | — | 132 |
| Colleton Medical Center | Walterboro | Acute Care Hospitals | 3 | 244 |
| Lexington Medical Center | West Columbia | Acute Care Hospitals | 3 | 1,142 |
| Three Rivers Behavioral Health | West Columbia | Psychiatric | — | 0 |