| Avera McKennan | Sioux Falls | 959 |
| Sanford Medical Center | Sioux Falls | 857 |
| Monument Health Rapid City Hospital Inc | Rapid City | 564 |
| Sanford Clinic | Sioux Falls | 268 |
| Black Hills Surgical Hospital LLC | Spearfish | 174 |
| Avera St Lukes | Aberdeen | 165 |
| Monument Health Network Inc | Spearfish | 160 |
| Rural Health Care Inc | Brookings | 154 |
| Sacred Heart Health Services | Yankton | 153 |
| Avera Queen of Peace | Mitchell | 122 |
| City of Brookings | Brookings | 115 |
| Prairie Lakes Health Care System Inc | Watertown | 109 |
| Pine Ridge Indian Health Service Hospital | Pine Ridge | 108 |
| Avera St Marys | Pierre | 97 |
| Black Hills Orthopedic and Spine Center Inc | Rapid City | 72 |
| Rosebud Indian Health Service | Rosebud | 72 |
| Great Plains Tribal Chairmen's Health Board | Rapid City | 67 |
| Heart Hospital of South Dakota LLC | Sioux Falls | 67 |
| Orthopedic Institute PC | Yankton | 57 |
| Horizon Health Care Inc | Wessington Springs | 55 |
| Sioux Falls Specialty Hospital, LLP | Sioux Falls | 52 |
| Rising Hope Counseling LLC | Burke | 49 |
| Madison Community Hospital | Madison | 47 |
| Urology Specialists Chartered | Sioux Falls | 47 |
| Huron Regional Medical Center Inc | Huron | 46 |
| Vance Thompson Vision Clinic Prof LLC | Sioux Falls | 45 |
| Eagle Butte Indian Health Service Hospital | Eagle Butte | 42 |
| Caring Edge Op LLC | Pierre | 36 |
| Siouxland Anesthesiology Ltd | Dakota Dunes | 34 |
| Anesthesiology Associates Inc | Sioux Falls | 26 |
| Vascular and Interventional Radiology of Siouxland | Rapid City | 25 |
| Anesthesia Physicians Ltd | Sioux Falls | 24 |
| Woodrow Wilson Keeble Memorial Health Care Center | Sisseton | 23 |
| Rapid City Emergency Services PA | Rapid City | 22 |
| Surgical Institute of South Dakota PC | Sioux Falls | 22 |
| Mobridge Regional Hospital | Mobridge | 21 |
| North American Baptist Seminary | Sioux Falls | 21 |
| City of Sioux Falls | Sioux Falls | 19 |
| The Imaging Center LLC | Rapid City | 18 |
| Radiology Associates Prof LLC | Rapid City | 18 |
| Vision Care Associates LLP | Sioux Falls | 17 |
| St Michael's Hospital, Inc. | Tyndall | 17 |
| Midwest Ear, Nose and Throat Associates P C | Sioux Falls | 17 |
| Center for Family Medicine | Sioux Falls | 16 |
| Behavior Management Systems Inc | Rapid City | 16 |
| Wagner Community Memorial Hospital | Wagner | 16 |
| Winner Regional Healthcare Center | Winner | 16 |
| Wagner Indian Health Service Health Center | Wagner | 16 |
| Sage Medical Prof LLC | Rapid City | 15 |
| West River Anesthesiology Consultants PC | Rapid City | 15 |
| Physicians Laboratory Ltd | Sioux Falls | 14 |
| Black Hills Regional Eye Institute LLP | Rapid City | 13 |
| Pain and Movement Solutions LLC | Belle Fourche | 13 |
| Avera Gettysburg | Gettysburg | 13 |
| St Benedict Health Center | Parkston | 13 |
| Ophthalmology Ltd | Mitchell | 12 |
| City of Redfield | Redfield | 12 |
| Community Health Center of the Black Hills Inc | Rapid City | 12 |
| Coteau Des Prairies Hospital | Sisseton | 12 |
| Ear Nose and Throat Consultants and Hearing Services PLC | Dakota Dunes | 12 |
| Northeastern Mental Health Center | Aberdeen | 11 |
| Siouxland Urology Associates PC | Dakota Dunes | 11 |
| Vital Care, LLC | Sioux Falls | 11 |
| Capital Area Counseling Service, Inc | Pierre | 11 |
| Modern Day Health Care Prof LLC | Aberdeen | 11 |
| Community Counseling Service | Huron | 11 |
| Lewis and Clark Behavioral Health Services Inc | Yankton | 11 |
| Flandreau Santee Sioux Tribe | Flandreau | 10 |
| Travis J Ptacek MD PLLC | Rapid City | 10 |
| Marshall County Memorial Hospital | Britton | 10 |
| Mk Counseling LLC | Sioux Falls | 10 |
| Black Hills Psychology LLC | Spearfish | 10 |
| Faulkton Area Medical Center | Faulkton | 10 |
| Pine Ridge Indian Health Service Hospital | Kyle | 10 |
| Manlove Psychiatric Group PC | Rapid City | 10 |
| Big Stone Therapies Watertown LLC | Watertown | 10 |
| Dunes Anesthesia PC | Dakota Dunes | 10 |